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Project Two
TRTx
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Project Two
APPLICATION. Presently available AWC biologics require prolonged and repeated applications at high concentrations. TRT-8174 may require a single or a very small number of applications at very low concentrations.
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THE LEAD COMPOUND, TRT-8174, is a novel and unique small synthetic chemical molecule designed to mimic the key three dimensional binding motif of MSF.
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Unlike other advanced wound care (AWC) medicines, MSF bioactives DO NOT INDUCE CELL PROLIFERATION.
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MSF bioactives show unprecedented POTENCY, eliciting half-maximal activity at femtomolar concentrations in tissue culture and promoting wound healing in vivo when using only 3-4 applications of picogram doses.
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SIGNAL TRANSDUCTION MECHANISMS show a clear distinction between MSF, which inhibits AKT activation on the target cells, and other factors used as AWC medicines, which commonly stimulate AKT activation.
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MSF bioactivity and expression is MODULATED BY THE EXTRACELLULAR MATRIX. This is relevant as it may be used to fine-tuning therapeutic intervention. Matrix modulation has not been reported for current AWC factors.
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MSF EXPRESSION MAY BE SWITCHED ON AND OFF in a reversible fashion.
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MSF bioactives INDUCE THE EXPRESSION OF ENDOGENOUS MSF PROTEIN by tissue cells.
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MANUFACTURING of TRT-8174 and other MSF mimetics is simple and inexpensive.
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