Fundamental Therapeutics for advanced wound healing
11 Dudhope Terrace, Dundee, DD3 6TS, UK


Apply the gel to gauze thinly (4-5 mm) in an area to cover the wound. Apply this to the wound and fasten a bandage to keep in place. Check the bandage after 3-4 days, and if necessary, re-apply. Seek veterinary advice if the wound is not improving.


Purified NZ water (aqua) (95%), trtx (5 ng/mL) in hydroxypropyl methyl cellulose (4.99%), DMSO (0.00005%).

Made in New Zealand

TRT Founders

TRT was founded by four scientists and is based on inventions resulting from their research. Dr Ana Schor and her late husband, Professor Seth Schor, identified and cloned Migration Stimulating Factor (MSF: a unique, highly potent, regulator of biological processes required for normal wound healing) and discovered a three-amino-acid peptide (IGD peptide) of MSF, which displays all of its biological activities. Dr David Norman, an expert in biological structure determination, elucidated the structure of IGD and with Dr Rudi Marquez, used that information to rationally design small-organic mimetics of IGD. Dr Rudi Marquez synthesised  a number of candidate mimetics including our lead compound, TRT-8174.  Drs Schor, Norman and Marquez are the current directors of TRT.


Our Science

The science and discoveries that have led to the founding of TRT are documented in a large number of scientific publications and patents. A selection of these publications are referenced on this page.

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Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL (2003). The use of growth factors in the treatment of chronic diabetic foot ulcers. Br J Surg 90:133-146.

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Schor SL, Schor AM, Keatch RP, Belch JJF (2005). Role of matrix macromolecules in the aetiology and treatment of chronic ulcers. In The Wound Management Manual (ed. BY Lee). McGraw Hill, New York. pp109-121.

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Shpiro N, Ellis IR, Dines TJ, Schor AM, Schor SL, Norman DG, Marquez R (2005). Synthesis of an IGD peptidomometic with motogenic activity. Mol Biosystems 1:318-320.

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Keatch RP. Schor AM, Vorstius JB, Schor SL (2012). Biomaterials in regenerative medicine: engineering to recapitulate the natural. Current Opinion in Biotechnology 23:579-582.

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Schor A.M, Schor SL (2010). Angiogenesis and tumour progression: migration-stimulating factor as a novel target for clinical intervention. Eye. 24:450-458.

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Schor SL, Ellis IR, Jones SJ, Woolston AM, Schor AM. (2012) Bi-stable epigenetic switch in MSF expression is regulated by the concerted signalling of TGF-beta1 and the extracellular matrix.. Int J Cancer. 130:2024-2032.

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Ellis IR, Jones SJ, Staunton D, Vakonakis I, Norman DG, Potts JR, Milner CM, Meenan NA, Raibaud S, Ohea G, Schor AM, Schor SL (2010a). Multi-factorial modulation of IGD motogenic potential in MSF (migration stimulating factor). Exp Cell Res. 316:2465-2476.

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Kay RA, Ellis IR, Jones SJ, Perrier S, Florence M, Schor AM, Schor SL (2005). The expression of MSF, a potent onco-fetal cytokine, is uniquely controlled by 3'UTR-dependent nuclear sequestration of its precursor mRNA. Cancer Res. 65: 10742-10749.

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Schor SL, Ellis IR, Jones SJ, Baillie R, Seneviratne K, Clausen J, Motegi K, Vojtesek B, Kankova K, Furrie E, Sales MJ, Schor AM, Kay RA (2003). Migration Stimulating Factor (MSF): A genetically-truncated fibronectin isoform expressed by carcinoma and tumor-associated stromal cells. Cancer Res. 63:8827-8836.

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Vakonakis I, Staunton D, Ellis IR, Sarkies P, Flanagan A, Schor AM, Schor SL, Campbell ID (2009). Motogenic sites in human fibronectin are masked by long range interactions. J. Biol. Chem. 284:15668-15675.

Skin Wounds Treatment

Problems associated with the healing of skin wounds result in much suffering and expensive treatments that are often unsatisfactory. There is a significant unmet medical need for an effective wound healing treatment, for both humans and animals, with a corresponding commercial opportunity.

Normal wound healing requires the influx of cells, matrix remodelling and the formation of new blood vessels at the wound site through a process collectively called “cell activation”. Once the skin has been repaired, the cells “de-activate”, thus returning to their original resting state. Normal wound healing reflects a balance between cell activation in response to tissue injury and cell de-activation at the completion of the healing process. Disruption of these processes can result in non-healing, chronic, ulcers (i.e. failure of cell activation) or excessive new tissue formation or scarring (i.e. failure of cell de-activation).

Our Company FAQs

Frequently Asked
Question from Our Clients

A specialized approach integrating advanced therapies for optimal wound recovery.

It goes beyond conventional methods, incorporating innovative therapeutic techniques for accelerated healing.

It addresses a spectrum of wounds, from acute injuries to chronic conditions, promoting overall wound health.

It's tailored to various patient needs, considering factors like wound type, severity, and individual health conditions.

Chronic skin ulcers are particularly common in the elderly and people with diabetes. Leg wounds in horses are often slow to heal and prone to develop excessive tissue or “proud fleshâ.

The Founders of TRT have identified a novel protein, Migration Stimulating Factor (MSF), which is not normally present in the skin but is transiently up-regulated during wound healing. MSF exhibits a number of potent bioactivities required for cell activation during the wound healing process. Its mode of action is uniquely different from that of other cell activation proteins. TRT’s founding scientists discovered that the activity of MSF resides primarily in a short peptide motif. Most importantly, they determined the structure of MSF’s active motif and developed small, stable and easily manufactured drug-like molecules – like the one in the upper right of this page – that mimic MSF, producing the same range of relevant therapeutic activities as the MSF protein. When applied to wounds on diabetic mice (a commonly-used preclinical model of impaired wound healing) these molecules significantly promoted wound healing at very low concentrations. In a recent horse trial, TRT’s lead compound stimulated wound healing in leg wounds and appeared to prevent proud flesh formation.

TRT is actively searching for partners and investors

Our Testimonial

What Client Say

Here are some clients praise Tissue Repair Technologies Limited for revolutionary solutions, impeccable results, and a commitment to cutting-edge advancements in tissue repair.

"Optimal healing experience! Fundamental Therapeutics' holistic approach impressed me. From cutting-edge treatments to personalized care, they set a new standard in advanced wound healing. A transformative journey indeed."

"A game-changer in wound healing! Fundamental Therapeutics exceeded expectations. The integrated techniques and individualized care showcase a commitment to excellence. Grateful for this innovative approach!"

"Exceptional care! Fundamental Therapeutics provided unparalleled support for my chronic wound. The advanced therapies and knowledgeable team made a significant difference. A true leader in wound healing solutions."


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Innovative Solutions from Tissue Repair Technologies herald a new era in regenerative medicine.

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